B I09

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

B I09 是 IRE-1 核糖核酸酶的一个抑制剂，其 IC50 值为 1230 nM。

B I09 is an IRE-1 RNase inhibitor, with an IC50 of 1230 nM.

B I09 is an IRE-1 RNase inhibitor, with an IC50 of 1230 nM. Treatment of CLL cells with this inhibitor (B I09) mimick XBP-1 deficiency, including upregulation of IRE-1 expression and compromised BCR signaling. B I09 is highly effective in inhibiting splicing of XBP1 mRNA in human WaC3 cells and the expression of XBP-1s in LPS stimulated B cells.

B I09 has a halflife of approximately 1.5 hours and reaches its peak concentration of approximately 39 μM in mouse plasma serum 15 minutes after administration. Administration of B I09 to CLL tumor-bearing mice suppress leukemic progression by inducing apoptosis and do not cause systemic toxicity.

——

Others

Other Targets

IRE1

——

——

1607803-67-7

303.31

C16H17NO5

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 8.33 mg/mL (27.46 mM; 超声助溶 )

Oc1ccc2c3CCNCc3c(=O)oc2c1C1OCCCO1

——

(-20℃)

With Ice Pack

≥ 2 years